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چکیده
T he fundamentals of structure and stereochemistry have been considered in previous chapters in some detail. There are, however, practical aspects of stereochemistry that have not yet been mentioned, particularly with regard to chiral compounds. How, for instance, can a racemic mixture be separated into its component enantiomers (resolution); what methods can be used to establish the configuration of enantiomers; how can we tell if they are pure; and how do we synthesize one of a pair of enantiomers preferentially (asymmetric synthesis)? In this chapter, some answers to these questions will be described briefly. Optical activity is an associated phenomenon of chirality and has long been used to monitor the behavior of chiral compounds. Brief mention of this was made earlier (Section 51 C), but now the origin and measurement of optical rotation will be examined in more detail.
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International Union of Biochemistry Joint Commission on Biochemical Nomenclature* Nomenclature and Symbols for Folic Acid and Related Compounds
Republication of this report is permitted without the need for formal IUPAC permission on condition that an acknowledgement, with full reference together with JUPAC copyright symbol (© 1987 JUPAC), is printed. Publication of a translation into another language is subject to the additional condition of prior approval from the relevant JUPAC National Adhering Organization. Synopsis — The folates ...
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